Scientists studying Brazil's unusually high number of supercentenarians – people who live far beyond the age of 100 – have made a remarkable discovery about how their supercharged immune systems help keep them healthy into extreme old age. Brazil is home to a disproportionate number of people who live past 110, making it a uniquely valuable setting for longevity research. On closer analysis, researchers found their immune systems – the body's first line of defence against infection – behaved very differently from those of the general population. The team also discovered that CD4+ 'helper' T cells, which normally coordinate immune responses, behaved more like CD8+ killer cells – immune cells that directly attack infected or abnormal cells. During the Covid pandemic, the researchers found these immune systems adapted rapidly, producing neutralising antibodies and boosting immune-related proteins involved in early viral defence.

THE selling agent for Gorsefield might as well shout out its best attribute — ‘The work is all done’ — because that’s what’s going to sell it, and likely in jig time too. The c 1950s/1960s four-bed semi-d featured in these pages in autumn of 2024, when it had an E1 BER, and carried a €540,000 asking price. Gorsefield in 2024, before the revampIn the event, it sold for €520,000, just under the asking price - unusual enough for an address like Cork’s Loreto Park, just off the South Douglas Road and near the Cross Douglas Road, where normally bidding drives prices over launch levels. The increase chimes with anecdotal accounts of current upgrades/extensions on dated semi-ds coming in at €200,000 to €300,000, and more again if substantially extended. Also showing with a Loreto ‘one t’ address is Trenton, in 2024 at €540,000, while a large detached called Lauderdale sold in 2023 at a recorded €877,500.

It is hard to believe it's been 10 years since the 'David's dead' gaffe on Celebrity Big Brother. The name was coined because of the iconic Celebrity Big Brother moment, with the tour poster showing Gest emerging from a coffin with 'Born 11.5.1953. And his successful appearances in Celebrity Big Brother and ITV's I'm A Celebrity... Get Me Out Of Here! The couple then married in June 2025Megan McKenna was best known for her appearances on Ex On The Beach when she took part in Celebrity Big Brother. Scotty TScotty T was crowned the winner of Celebrity Big Brother 17 after viewers voted him their champion on Day 32Scotty T was crowned the winner of Celebrity Big Brother 17 after viewers voted him their champion on Day 32.

Nicola Peltz pointedly paid tribute to 'my crew' as she shared family snaps to her socials on Saturday - after deleting all traces of the Beckhams on Instagram amid her and her husband Brooklyn's feud with them. The actress, 31, removed all traces of the Beckham family from her social media after her husband Brooklyn blocked his parents and brothers. Brooklyn's younger brother Cruz previously confirmed that Brooklyn had blocked his entire family on social media following reports they had unfollowed him. I keep seeing everywhere that word, 'feud, feud, feud!?' It was the most public sign yet that there has is no communication between them amid their spiralling family feud.

‘Ireland is a target’ — new calls for hard focus on national securityBusiness chiefs say ‘hostile state actors’ are trying to infiltrate Irish firmsFormer taoiseach Bertie Ahern believes US president Donald Trump will not follow through on Greenland threatFormer taoiseach Bertie AhernNiamh Horan and Maeve Sheehan Today at 06:30A study published last month by the Institute of International and European Affairs (IIEA) has urged the Government here to speedily publish a National Security Strategy.

My favourite room: ‘All my life I’ve wanted a double-height ceiling’ – Inside sustainable style guru Sandra Walsh’s Co Louth new buildSandra Walsh was a stalwart of the Dublin fashion scene for many years, then in 2012 returned to her first career as a nurse. However,she’s now combining both passions thanks to a lovely interior feature of her stunning new home in county LouthFashion aficionado Sandra Walsh in the kitchen of her lovely home in Baltray, Co Louth. The lemon vase from Little Strand Antiques is one of her favourite things. Sandra Walsh and her husband Barry did things differently – they not only moved to quite a large house, they even moved to a different county. And in Sandra’s case, it was the new house itself which provided the impetus for her new project.

Overloaded energy grid threatens to delay major transport projects including MetrolinkWorkers on rail link may be forced to stop work during peak times, officials warnedIreland’s Transport Projects Face Delays Amid Electricity Grid Strain, ESB WarnsWayne O'Connor Today at 06:30Major transport projects are at risk of being delayed due to the huge demand already being placed on the energy grid.

‘I am not fatalistic about this’ – Agriculture Minister Martin Heydon moves to reassure farmers over Mercosur dealFine Gael TD says protections are in place to counter any major disruption to beef pricesAgriculture Minister Martin HeydonMary Regan Today at 06:30The Agriculture Minister, Martin Heydon, has urged farmers not to feel “fatalistic” about the Mercosur trade deal, saying safeguards are in place to protect them from any major disruption to beef prices from South American produce flooding the market.

He will also face a race to recover in time for this summer’s World Cup, should Northern Ireland qualify through the play-offs. Liverpool FC can confirm Conor Bradley has sustained a significant knee injury. Bradley had made 21 appearances this season, having missed a number of matches with a hamstring problem. Slot has had to utilise midfielders Dominik Szoboszlai and Curtis Jones in the position this season. But, with a host of players unavailable for the visit of Barnsley, there will be no chopping and changing at Anfield.

HamnetCert: 12A, 2hrs 5minsRating:Famously, little is known of the private life of William Shakespeare, still less that of his wife, Anne Hathaway, and it is important to remember that as Hamnet weaves its enchanting spell. When she and Will consummate their new love, it seems entirely fitting that they do so in an apple store. Their first daughter she delivers herself in her beloved greenwood, the twins that soon follow, Hamnet and Judith, she is forced to have at home. Buckley is quite wonderful, while Mescal provides cleverly judged support, but the casting – and acting – are exquisite throughout. Joe Alwyn is quietly splendid as Agnes’s supportive brother, Bartholomew, while young Jacobi Jupe makes Hamnet as loveable and intelligent a little boy as you could imagine.

It comes after the storm brought gusts of almost 100mph and a rare red warning for “dangerous, stormy” winds in the South West was issued by forecasters earlier this week. Despite the worst of the storm moving away, weather warnings are in place across northern England and Scotland throughout Sunday, with two alerts continuing into Monday morning. In south-west Scotland, Lothian Border and Strathclyde, a yellow warning for rain is in place until the end of Sunday. An amber alert for snow in Scotland has been lifted by the weather service, along with one for rain in Northern Ireland. Met Office forecaster Craig Snell said a new weather system is expected to bring milder conditions and rain during a “messy transition” from Storm Goretti.

Just five days earlier the England Under-21 international was at Championship side Watford, where he spent the first half of the season on loan from City. That arrangement had been expected to continue but injuries to Josko Gvardiol and Ruben Dias left City manager Pep Guardiola, already without John Stones, short of defensive options. Academy graduate Alleyne was promptly recalled and thrown straight into the side for Wednesday’s 1-1 Premier League draw with Brighton. “We’re in every competition and the aim is to win everything,” said Alleyne. “It was at Watford as well, to win the league and get promoted.

Presented in move-in condition, it has been extended and upgraded, with bright living spaces, a kitchen-diner opening to a sunroom, and a south-facing rear garden. 8 Weston Close, Wicklow Town – €397,0008 Weston Close, Wicklow Town, Co Wicklow. Within walking distance of The Murrough and Wicklow Harbour, both monitored bathing waters, this three-bedroom detached bungalow extends to 85 sqm. Sat on an elevated site in a quiet cul-de-sac, it offers sea views, a west-facing private rear garden and a compact, single-storey layout. Wicklow town centre, the train station and coastal walks are all close by.

Ms Sturgeon herself has been keen to give the impression of someone who has embarked on a new life outside the cut and thrust of Holyrood. Mr Pedersen, who suggested that Ms Sturgeon had embarked on a "rock star tour" to promote Frankly, asked whether launching herself as a writer had made her happy. Ms Sturgeon said: "I’ve loved it. I feel younger than I have felt in a long, long time. It is a view those close to Ms Sturgeon reject.

People living in Chipping Norton and the Oxfordshire Cotswolds enjoyed snow that has stuck last week. While the week prior to that, people living in Oxford were also treated to snow - albeit a flurry that didn't last long and failed to stick around. And unlike last week, there are no weather warnings in place for snow, ice or even rain this coming week. The BBC Weather spokesman said Monday "will start with variable cloud, some bright spells and the odd spot of rain". With the rain set to fall for most days this week, there is currently no snow forecast for Oxford or Oxfordshire.