The following question arises: may other SARS-CoV-2 variants arise that incorporate genes from homologous or heterologous viruses or even cellular genes, and might such viruses have novel properties that increase the transmission, immune evasion, or virulence? A second jump from the end of the heterologous message back to the genome would result in the insertion of the heterologous gene into a full length minus stand. When copied into a full-length positive-strand would result in the inclusion of the heterologous gene into newly formed genomes. FIGURE 1: (A) Insertion of a heterologous protein from a heterologous virus inserted into a ... [+] betacoronavirus during genomic mRNA replication. compared the ability of the bat coronavirus-derived P10 protein to initiate cell to cell fusion with the P10 protein isolated in an authentic orthoreovirus (Palau).
Source: Forbes April 01, 2022 18:52 UTC