Summary: Researchers uncovered an association between specific microRNAs and COVID-19 severity in a group of 259 unvaccinated patients. This study provides the first genomic picture of blood microRNAs in COVID-19 patients from the Middle East, North Africa, and South Asia. Key Facts:Researchers created the first genomic blueprint of blood microRNAs in COVID-19 patients from MENA and South Asia. The nature and magnitude of miRNA perturbations associated with blood phenotypes and intensive care unit (ICU) admission in COVID-19 are poorly understood. ConclusionsThis systems genetics study has given rise to a genomic picture of the architecture of whole blood miRNAs in unvaccinated COVID-19 patients and pinpoints post-transcriptional regulation as a potential mechanism that impacts blood traits underlying COVID-19 severity.

Source: The North Africa Journal June 12, 2023 23:41 UTC