There are many lessons we can take away from the ways in which SARS-CoV-2 works to suppress and evade the innate immune system. The first lesson is that when we talk about innate immunity, we tend to conflate two arms of the immune system that warrant clear distinction. The second lesson we’ve learned is that more components of innate immunity are essential to its general functioning than we initially thought. It appears that suppression of innate immunity allows SARS-CoV-2 to replicate to higher titers more efficiently, peaking before symptoms begin to show. The third lesson, to the previous point, is that the innate immune system is a target-rich environment ripe for drug development.

Source: Forbes November 02, 2021 00:52 UTC