DKTK is a consortium centered around the German Cancer Research Center (DKFZ) in Heidelberg, which has long-term collaborative partnerships with specialist oncological centers at universities across Germany. Mice with the mutated PI3K gene developed mostly biliary tract cancer, mice with the mutated KRAS gene instead developed exclusively pancreatic cancer. "Understanding the genetic interactions in different cancer types will guide more precise therapeutic decision making in the future" says Gunter Schneider, Professor for Translational Cancer Research at the University Medical Center Gottingen. "Our ability to engineer specific genetic alterations in mice allows us to study the function of cancer genes and to model specific cancer subtypes. Several of the authors including Dieter Saur and Roland Rad are based at TranslaTUM, TUM's Center for Translational Cancer Research.

Source: Hindustan Times July 25, 2021 02:03 UTC