Correlation between KRAS and NRAS mutational status and clinicopathological features in 414 cases of metastatic colorectal cancer in Morocco: the largest North African case series - BMC Gastroenterolo
RAS mutation is an early event in colorectal carcinogenesis. In absence of metastatic and recurrent CRC tissues, primary tumor tissue is an acceptable alternative [29, 30]. For correlation of primary tumor localization and RAS mutation, literature also was controversial. In many studies, KRAS mutation incidence was higher in right-sided than in left-sided colon tumors [34,35,36] and higher in women [34, 36, 37] but not for NRAS mutation [34, 35]. Other studies did not find differences in location of primary tumor [37, 38] and patients’ gender [38] for KRAS mutation prevalence.
Source: The North Africa Journal June 05, 2023 11:08 UTC
