“Our findings are consistent with the latest randomized, controlled trial.” She spoke in a plenary presentation about the study findings at the annual meeting of the American College of Rheumatology. Knee replacement or joint space width worsening at the tibial femoral joint was also more likely 120 injection knees than 2,112 non-injection knees (OR, 1.64; 95 percent CI, 0.91-2.93). In another analysis, researchers tracked 134 injection knees (58 whose OA progressed) and 498 noninjection knees (132 whose OA progressed) for up to eight years. After adjustment, the injection knees were more likely to have progressed (hazard ratio, 1.60; 95 percent CI, 1.21-2.12). “Several explanations may account for our study findings,” is that corticosteroids may hurt chrondocytes by, among other things, inducing apoptosis and synovial membrane inflammation.

Source: Philippine Star March 16, 2019 16:00 UTC