Studies show immunotherapy improves long-term survival in growing number of cancers
Immunotherapy improves long-term overall survival in patients with advanced melanoma, according to the results of a number of large international studies reported at ESMO 2024. “At ESMO 2024 we are seeing many studies in many different cancers showing that immunotherapy can work for a long time.”Results of a phase 3 trial of immunotherapy with an anti–programmed death (PD)-1–based therapy showed continued long-term survival benefit in patients with advanced melanoma. The melanoma-specific survival is very high in this group of patients.”Importantly, the long-term survival benefit with immunotherapy is also seen in routine clinical practice, outside clinical trials, Dr Donia continued. Results showed a statically-significant and clinically meaningful improvement in overall survival with immunotherapy plus chemotherapy before surgery and continued immunotherapy after surgery; the five-year overall survival rate was 86.6 per cent in patients given immunotherapy and 81.2 per cent in the placebo group. The phase 3 NIAGARA study randomised patients to immunotherapy with durvalumab plus chemotherapy before radical cystectomy followed by continued immunotherapy or to only chemotherapy before surgery.
Source:Irish Independent
November 18, 2024 22:41 UTC
Winter hits Klamath, Tulelake basins, snowfall, high winds forecasted
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Source:The Herald
November 18, 2024 22:38 UTC
Athlone club named Triathlon Ireland Club of the Year
Athlone Triathlon Club chairperson Gerald Lynch (fourth from left) and PRO Laura Kelly along with other club members at the Triathlon Ireland Awards. Athlone Triathlon Club named Ireland's Club of the YearAthlone Triathlon Club have been named Triathlon Ireland Club of the Year at the Triathlon Ireland Awards 2024The ceremony was held in the Carlton Hotel in Blanchardstown on Sunday, November 17. Taking to social media to share their joy, the club wrote: "An incredibly proud moment for our club and our members. And the perfect end to what has been an unforgettable year for ATC. Thank you to Triathlon Ireland for recognising our dedication, not just to the sport of triathlon, but to the values of community, connection, and excellence that make ATC so special."
Source:Irish Independent
November 18, 2024 22:36 UTC
Northern Ireland earn Nations League promotion despite draw with Luxembourg
It set up a tense finish at the Stade de Luxembourg but Northern Ireland hung on and the point, coupled with a 1-1 draw between Bulgaria and Belarus, saw them top the group by two points. It was almost a repeat a minute later as Northern Ireland got their goal. Five minutes into the second half Northern Ireland were celebrating again, thanks in large part to a howler from goalkeeper Tiago Pereira. Bradley’s header from Price’s cross should have been routine for the goalkeeper but Pereira somehow let it squirm past him – giving Bradley the 100th Northern Ireland goal of O’Neill’s two spells in charge. Schon was stretching moments later to keep out Galbraith’s shot as the game opened up, but it stayed level and Northern Ireland hung on.
Source:The Herald
November 18, 2024 22:13 UTC
Kawasaki rider wanted after fleeing scene of Wantage crash
The crash, which involved a Kawasaki motorcycle, was in Mill Street, Wantage, at around 1pm yesterday, Sunday, November 17. Police are appealing for witnesses because they think the rider may have suffered injuries. “The rider of a Kawasaki motorcycle has been involved in a single vehicle collision where they have subsequently fled the scene and may have sustained injuries. At this time, the identity of the rider is unknown. We are concerned for the rider's welfare following the incident.
Source:The Herald
November 18, 2024 20:39 UTC
Four wreaths placed on Drummer’s grave for Armistice Day
Johnny Kelly, Adrian Earley, Paul Cooley, John McCrossan, Jim Cleary and Paddy CostelloFour wreaths placed on Drummer’s grave for Armistice DayPrevious Next Image 1 of 1 BELOW: The full group at the Drummer Flynn memorial in Cornamagh. by David FlynnOn Armistice Day, November 11, a group of ex-soldiers performed their annual ceremony at the memorial for 19th century Athlone soldier, Drummer Thomas Flynn in Cornamagh Cemetery. At the monument honouring Drummer Flynn, Paul Cooley laid a wreath on behalf of ONE, Jim Cleary laid a wreath on behalf of MPAI, John McCrossan laid a wreath on behalf of IUNVA and Paddy Costello (Post 9) laid the poppy wreath. Drummer Flynn was 17 years old when he became an Irish recipient of the Victoria Cross, making him one of the youngest recipients of the medal. He had been a drummer in the 64th Regiment of Foot (later the North Staffordshire Regiment), an infantry regiment, in 1857 in India
Source:Irish Independent
November 18, 2024 19:37 UTC
Man pleads guilty over ‘death threat’ gun video posted after Southport attacks
Khan admitted his guilt during a hearing at Birmingham Crown Court (PA Archive)Khan, of Hickman Road, Sparkbrook, pleaded guilty on Monday at Birmingham Crown Court to a charge of sending a communication threatening death or serious harm. No details of the video were given to the court, but a previous hearing was told Khan was seen brandishing what appeared to be an AK-47. The previous hearing was also told that the video was viewed more than 1.4 million times on social media. Khan pleaded not guilty to a second charge of possessing an imitation firearm, a plea which the Crown accepted. Adjourning the case, Judge Melbourne Inman KC told Khan: “You will be sentenced on the 19th of December.
Source:The Herald
November 18, 2024 19:25 UTC
Cannabis users spiked with heroin while dealers offer free cocaine to expand their market
Young cannabis users are being spiked with heroin and pushed to take cocaine by dealers intent on hooking them to expand their market. Free samplesHe said cannabis users as young as 13 and 14 have told him they have been given free samples of cocaine to try. He said it is not unusual for cocaine users to say their habit is costing them between €1,000 and €1,500 a week. Heroin dealers are also pushing the drug on cocaine users and crack cocaine users to medicate the cocaine ‘come-down’, Mr Guerin said. “Most towns in Co Cork now have some heroin users,” a Garda source said.
Source:Irish Examiner
November 18, 2024 19:00 UTC
HDU admissions at Rotunda often exceed capacity
Admissions to the high-dependency unit (HDU) at the Rotunda Hospital in Dublin have increased by 76 per cent since 2018. The report noted that admissions to the HDU often surpassed bed capacity. Gynaecology admissions rose significantly in 2023, which was “most likely” due to a higher surgical caseload through additional theatre capacity. There are two beds designated for high dependency care, with staffing capacity for a maximum of two admissions. The Rotunda also has a pathway to ICU beds at the nearby Mater Misericordiae University Hospital, for women requiring higher-level intensive care.
Source:Irish Independent
November 18, 2024 18:30 UTC
Ireland captain Caelan Doris on four-man shortlist for world player of the year
Ireland captain Caelan Doris on four-man shortlist for world player of the yearBy PA Sport StaffIreland captain Caelan Doris is among four nominations for World Rugby men’s player of the year. The 26-year-old number eight led Ireland to an away Test victory over world champions South Africa this summer and was also a key member of Ireland’s Six Nations title-winning team last season. Doris would become the fourth Irishman to win the award if he triumphs, after Keith Wood, Johnny Sexton and Josh van der Flier. He is joined on the shortlist by three Springboks – former winner Pieter-Steph du Toit, lock Eben Etzebeth and wing Cheslin Kolbe. England wing Immanuel Feyi-Waboso, meanwhile, is among the nominations for men’s breakthrough player of the year, joining Ireland centre Jamie Osborne, South Africa back Sacha Feinberg-Mngomezulu and New Zealand flanker Wallace Sititi.
Source:Irish Independent
November 18, 2024 18:28 UTC
Council needs more doctors to step forward as medical experts
The Medical Council President has encouraged more doctors to consider acting as medical experts. The current shortfall is contributing to delays in the Council’s complaints process. Dr Suzanne Crowe told the Medical Independent (MI) the Council may have to wait many months for an expert report. A recent survey by Medical Protection Society found that the length of Council investigations was a major stressor for doctors going throughthis process. It is a free 24/7 service available to doctors, medical students, and members of the public who are engaging with any of the Council’s regulatory processes.
Source:Irish Independent
November 18, 2024 18:23 UTC
Election 2024: See the full list of candidates in your constituency
Tomas DohertyMore than 680 general election candidates are running for the Dáil across the State’s 43 constituencies. The deadline for nominations passed at the weekend and returning officers have now published the final list of candidates in each area. Below you can see who is standing in this year’s general election. Use the search bar to find candidates in your constituency. The constituency with the most candidates is Louth at 24, while only 10 people are standing in Wicklow-Wexford.
Source:The Herald
November 18, 2024 18:08 UTC
Karma's calling, FSU Seminoles: Get rid of the stupid Tomahawk Chop, War Chant | Opinion
And trust me, these examples are only some of the recent indignities experienced by the Seminoles football program – which has also become the target of some pretty masterful trolling. Not by accidentBut I don't believe the Seminoles football program's ongoing misfortune is by accident or coincidence. Nope, I’m convinced it’s pure, simple, cold-blooded cosmic payback for FSU’s shameful embrace of the stupid Tomahawk Chop and War Chant – both of which continue to perpetuate some of the dumbest stereotypes that exist regarding Native Americans. Because let's be clear about this: The Tomahawk Chop and War Chant are offensive behaviors. So why should FSU continue to get away with allowing the Tomahawk Chop and War Chant?
Source:The Herald
November 18, 2024 17:41 UTC
Election 2024 live updates: Micheál Martin ‘surprised’ at Taoiseach’s support of candidate John McGahon after ‘quite shocking’ assault
Meanwhile, Martin was asked about the John McGahon controversy on a podcast hosted by Newstalk’s Seán Defoe. “Let’s be clear, that person would not be candidate for Sinn Féin,” he said. Photograph: Jennifer BrayGreen Party leader Roderic O’Gorman was asked about the controversy around John McGahon, political correspondent Jennifer Bray reports. Ms Gibney was responding to a question about Fine Gael election candidate in Louth, John McGahon who was involved in a fight outside a pub in Dundalk in 2018. Mr White was awarded €39,000 after he sued the Louth Fine Gael candidate for assault and battery.
Source:The Irish Times
November 18, 2024 17:35 UTC
Jonesborough celebrates Jackson Theater's historic comeback
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Source:The Herald
November 18, 2024 17:13 UTC